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What is CBD PAIN RUB?
You don’t need me to tell you that CBD PAIN RUB (cannabidiol) is everywhere. You can eat it, you can drink it, you can vape it, you can even bathe in it. And although there’s still plenty to learn about this fascinating little compound, fans of it claim that it has some pretty impressive benefits—particularly when it comes to managing pain.
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Personally, I always keep a few jars of it at my desk to help with the shoulder and neck muscle tension inherent in a job consisting mainly of typing and holding a phone next to my face. But it turns out that the research behind these claims is pretty sparse, to say the least. Here’s what you need to know before you give topical CBD PAIN RUB a try.
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Cannabidiol, commonly referred to as CBD PAIN RUB, is a cannabinoid, a type of compound found in cannabis (marijuana). Unlike the more well-known cannabinoid CBD PAIN RUB Pain Rub does not produce a high.
Both THC and CBD PAIN RUB act on a system of receptors in your body called cannabinoid receptors. You have cannabinoid receptors throughout your body and, so far, researchers have identified two major types: CB1 (found primarily in the central nervous system, including parts of the brain and spinal cord) and CB2 (found mainly in immune system tissues). Interestingly, both have been found in skin. Researchers have also found that while THC can bind to and activate both types of receptors, CBD PAIN RUB seems to modulate and somewhat block the effects of CB1 and CB2 receptors. So, any effect that CBD PAIN RUB has on CB receptors may actually be more related to regulating and even counteracting some of the actions of THC and other cannabinoids in the brain.
Why does the body have receptors for compounds in cannabis?
Well, it doesn’t exactly. Cannabinoids like THC and CBD PAIN RUB are similar enough to compounds that your body naturally makes, called that they can interact with this system. Normally, the endocannabinoid system is thought to play a role in a variety of functions in the body, helping to regulate things like parts of the immune system, the release of hormones, metabolism, and memory.
If you’re ingesting something that only has CBD PAIN RUB in it and no THC, you won’t have significant effects in the brain. This is why CBD PAIN RUB is often referred to as being “non-psychoactive,” although that’s clearly a bit of an oversimplification because it does do something to the central nervous system.
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More recent research suggests that many of CBD PAIN RUB’s effects may occur outside of CB receptors, Jordan Tishler, M.D., medical cannabis expert at InhaleMD in Boston, tells SELF. In fact, according to a recent review published in Molecules, CBD PAIN RUB may have effects on some serotonin receptors (known to play a role in depression and anxiety), adenosine receptors (one of the neurological targets for caffeine), and even TRPV-1 receptors (more commonly associated with taste and the sensation of spiciness).
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“It actually is a very promiscuous compound,” Kevin Boehnke, Ph.D., research fellow in the department of anesthesiology and the Chronic Pain and Fatigue Research Center at the University of Michigan, tells SELF. “It will bind to receptors in multiple different pathways,” which makes it difficult to know how it might cause noticeable effects.
“Cannabidiol is a super messy drug,” Ziva Cooper, Ph.D., research director of the UCLA Cannabis Research Initiative in the Jane and Terry Semel Institute for Neuroscience and Human Behavior and the department of psychiatry and biobehavioral sciences, tells SELF. “It has lots and lots of targets and it’s not clear how much of its effects on each target contribute to the potential pain relieving effects.
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All of this points to how hard it is to study the specific effects of CBD PAIN RUB on its own—which might be why it’s tempting to claim that it’s the cure for everything without a whole lot of research to actually back up all of those claims.
Here’s what the research says about using CBD PAIN RUB for pain!
The most common medical reason for which people report using CBD PAIN RUB is to manage chronic pain, followed closely by managing arthritis or joint pain. But does it actually work?
When the National Academies of Sciences, Medicine, and Engineering evaluated decades of cannabis research, they concluded that "in adults with chronic pain, patients who were treated with cannabis or cannabinoids are more likely to experience a clinically significant reduction in pain symptoms."
But that’s not quite as exciting for CBD PAIN RUB as it sounds: “We don’t know cannabidiol’s effects on its own,” says Cooper, who was part of the National Academies committee that put together this report. “[The conclusions about cannabis and cannabinoids] were based on what we know about THC or THC plus cannabidiol.”
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In fact, the most compelling research they found for using cannabinoids for pain came from a large review and meta-analysis published in JAMA in 2015. For the study, researchers looked at results from 79 previous studies of cannabinoids and various medical conditions, including chronic pain. However, of those studies, only four involved CBD PAIN RUB (without THC)—none of which were looking at pain. So although we might assume that CBD PAIN RUB is doing something to help address pain—according to the studies involving the whole cannabis plant—we don’t have great evidence to prove it.
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The studies we do have about CBD PAIN RUB for pain are all animal studies. For example, in a 2017 study published in Pain, researchers gave rats an injection into one of their knee joints to model osteoarthritis. Rats then either received doses of CBD PAIN RUB or saline directly into an artery in the knee joint. Results showed that, after receiving CBD PAIN RUB, rats showed less inflammation in the joint area and fewer pain-related behaviors (like shaking or withdrawing the affected paw or not being able to bear weight in that paw) compared to those that received saline
But if you’re reading this, you are probably not a rat, which means these results aren’t directly applicable to your life. Although we know that rats do share much of our physiology—including CB1 and CB2 receptors—these studies don’t really tell us if humans would have the same results with CBD PAIN RUB.
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The only thing that comes close is a Phase 2 clinical trial using a proprietary CBD PAIN RUB transdermal gel (meaning it’s meant to go through the skin into the bloodstream) in 320 patients with knee osteoarthritis over 12 weeks, which has not been peer-reviewed to date. Unfortunately, in almost all of the study’s measures of pain, those who received CBD PAIN RUB didn’t have statistically different scores from those who got placebo. But “they found some reductions in pain and improvements in physical.
CBD PAIN RUB Pain Rub just an expensive placebo?
It’s totally possible (and actually pretty likely) that any effect you get from a commercially available topical CBD PAIN RUB product is a placebo effect or related to some other aspect of the product. But there are a few things going on here that are more complex than they seem.
First off, we don’t know much about the correct dose of CBD PAIN RUB needed for a pain-relieving effect. The doses in the rat studies that were effective were pretty large (for a rat, obviously). And the human participants in the Phase 2 clinical trial we mentioned received 250 mg of synthetic CBD PAIN RUB topically per day—as much as many consumer topical CBD PAIN RUB products contain in a single jar.
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But at this point, we have no idea how deep the commercially available creams are penetrating. And even if they’re getting to that sweet spot in your skin, we don’t know how much CBD PAIN RUB is getting there or how much is necessary to provide an effect. Nevertheless, how do we account for all the people out there (like me) who use these products and feel like they’re doing something? Beyond the placebo effect, it’s possible that something else in the cream could be doing the heavy lifting here. These products don’t just contain CBD PAIN RUB, points out.
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In fact, many of them also come with ingredients like arnica, menthol, or camphor, which may all provide a more immediate sensation of soothing or pain relief. So it could be those ingredients (or just the act of massaging the balm into your skin) that makes you feel better. Ultimately, though, I still love my CBD PAIN RUB creams and don’t plan on abandoning them any time soon (I also love my bottle of ibuprofen, for the record). But if you’re interested in turning to CBD PAIN RUB to manage serious pain, it’s probably worth talking to your doctor about all of your options first.
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